Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-kappaB signaling pathways in N9 microglia induced by lipopolysaccharide.

Zhang, Lijia

Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-kappaB signaling pathways in N9 microglia induced by lipopolysaccharide. [electronic resource] - International immunopharmacology Mar 2010 - 331-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1878-1705

10.1016/j.intimp.2009.12.004 doi


Animals
Anti-Inflammatory Agents
Biphenyl Compounds
Blotting, Western
Cell Survival--drug effects
Curcumin--analogs & derivatives
Diarylheptanoids
Down-Regulation--drug effects
Inflammation--chemically induced
Interleukin-1beta--biosynthesis
Lipopolysaccharides--antagonists & inhibitors
Macrophage Activation--drug effects
Mice
Microglia--drug effects
Mitogen-Activated Protein Kinases--metabolism
NF-kappa B--metabolism
Nitric Oxide--biosynthesis
Nitric Oxide Synthase Type II--metabolism
Nitrites--metabolism
Picrates
Reactive Oxygen Species--metabolism
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction--drug effects
Tumor Necrosis Factor-alpha--biosynthesis