The GPIIbIIIa antagonist drugs eptifibatide and tirofiban do not induce activation of apoptosis executioner caspase-3 in resting platelets but inhibit caspase-3 activation in platelets stimulated with thrombin or calcium ionophore A23187. [electronic resource]
Producer: 20100218Description: 1783-4 p. digitalISSN:- 1592-8721
- Apoptosis -- drug effects
- Blood Platelets -- cytology
- Calcimycin -- pharmacology
- Caspase 3 -- metabolism
- Coagulants -- pharmacology
- Enzyme Activation -- drug effects
- Eptifibatide
- Flow Cytometry
- Humans
- Ionophores -- pharmacology
- Peptides -- pharmacology
- Platelet Aggregation Inhibitors -- pharmacology
- Platelet Glycoprotein GPIIb-IIIa Complex -- antagonists & inhibitors
- Thrombin -- pharmacology
- Tirofiban
- Tyrosine -- analogs & derivatives
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Publication Type: Letter; Research Support, Non-U.S. Gov't
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