The GPIIbIIIa antagonist drugs eptifibatide and tirofiban do not induce activation of apoptosis executioner caspase-3 in resting platelets but inhibit caspase-3 activation in platelets stimulated with thrombin or calcium ionophore A23187.
Leytin, Valery
The GPIIbIIIa antagonist drugs eptifibatide and tirofiban do not induce activation of apoptosis executioner caspase-3 in resting platelets but inhibit caspase-3 activation in platelets stimulated with thrombin or calcium ionophore A23187. [electronic resource] - Haematologica Dec 2009 - 1783-4 p. digital
Publication Type: Letter; Research Support, Non-U.S. Gov't
1592-8721
10.3324/haematol.2009.012708 doi
Apoptosis--drug effects
Blood Platelets--cytology
Calcimycin--pharmacology
Caspase 3--metabolism
Coagulants--pharmacology
Enzyme Activation--drug effects
Eptifibatide
Flow Cytometry
Humans
Ionophores--pharmacology
Peptides--pharmacology
Platelet Aggregation Inhibitors--pharmacology
Platelet Glycoprotein GPIIb-IIIa Complex--antagonists & inhibitors
Thrombin--pharmacology
Tirofiban
Tyrosine--analogs & derivatives
The GPIIbIIIa antagonist drugs eptifibatide and tirofiban do not induce activation of apoptosis executioner caspase-3 in resting platelets but inhibit caspase-3 activation in platelets stimulated with thrombin or calcium ionophore A23187. [electronic resource] - Haematologica Dec 2009 - 1783-4 p. digital
Publication Type: Letter; Research Support, Non-U.S. Gov't
1592-8721
10.3324/haematol.2009.012708 doi
Apoptosis--drug effects
Blood Platelets--cytology
Calcimycin--pharmacology
Caspase 3--metabolism
Coagulants--pharmacology
Enzyme Activation--drug effects
Eptifibatide
Flow Cytometry
Humans
Ionophores--pharmacology
Peptides--pharmacology
Platelet Aggregation Inhibitors--pharmacology
Platelet Glycoprotein GPIIb-IIIa Complex--antagonists & inhibitors
Thrombin--pharmacology
Tirofiban
Tyrosine--analogs & derivatives