Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53. [electronic resource]
Producer: 20091202Description: 1562-74 p. digitalISSN:- 1460-2105
- Administration, Oral
- Animals
- Antineoplastic Agents -- administration & dosage
- Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
- Caspase 3 -- metabolism
- Caspase 7 -- metabolism
- Cell Cycle -- drug effects
- Cell Line, Tumor
- DNA Fragmentation
- Diploidy
- Drug Resistance, Neoplasm
- Female
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Imidazoles -- administration & dosage
- Immunoblotting
- Immunohistochemistry
- Mice
- Mice, Nude
- Mutation
- Neuroblastoma -- drug therapy
- Piperazines -- administration & dosage
- Proto-Oncogene Proteins c-mdm2 -- antagonists & inhibitors
- Reverse Transcriptase Polymerase Chain Reaction
- Transplantation, Heterologous
- Tumor Suppressor Protein p53 -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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