Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53.

Van Maerken, Tom

Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53. [electronic resource] - Journal of the National Cancer Institute Nov 2009 - 1562-74 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1460-2105

10.1093/jnci/djp355 doi


Administration, Oral
Animals
Antineoplastic Agents--administration & dosage
Antineoplastic Combined Chemotherapy Protocols--therapeutic use
Caspase 3--metabolism
Caspase 7--metabolism
Cell Cycle--drug effects
Cell Line, Tumor
DNA Fragmentation
Diploidy
Drug Resistance, Neoplasm
Female
Gene Expression Regulation, Neoplastic--drug effects
Humans
Imidazoles--administration & dosage
Immunoblotting
Immunohistochemistry
Mice
Mice, Nude
Mutation
Neuroblastoma--drug therapy
Piperazines--administration & dosage
Proto-Oncogene Proteins c-mdm2--antagonists & inhibitors
Reverse Transcriptase Polymerase Chain Reaction
Transplantation, Heterologous
Tumor Suppressor Protein p53--drug effects