Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities. [electronic resource]
Producer: 20091221Description: 7228-35 p. digitalISSN:- 1520-4804
- Animals
- Antineoplastic Agents -- chemistry
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cell Transformation, Neoplastic
- Chalcone -- analogs & derivatives
- Chalcones -- chemistry
- Female
- Genes, Reporter
- Humans
- I-kappa B Kinase -- antagonists & inhibitors
- Inhibitory Concentration 50
- Interleukin-1 Receptor-Associated Kinases -- antagonists & inhibitors
- Luciferases -- metabolism
- Lung Neoplasms -- drug therapy
- Mice
- Mice, Nude
- NF-kappa B -- antagonists & inhibitors
- Structure-Activity Relationship
- Tumor Necrosis Factor-alpha -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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