Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities.

Srinivasan, Balasubramanian

Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities. [electronic resource] - Journal of medicinal chemistry Nov 2009 - 7228-35 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1520-4804

10.1021/jm901278z doi


Animals
Antineoplastic Agents--chemistry
Cell Line, Tumor
Cell Proliferation--drug effects
Cell Transformation, Neoplastic
Chalcone--analogs & derivatives
Chalcones--chemistry
Female
Genes, Reporter
Humans
I-kappa B Kinase--antagonists & inhibitors
Inhibitory Concentration 50
Interleukin-1 Receptor-Associated Kinases--antagonists & inhibitors
Luciferases--metabolism
Lung Neoplasms--drug therapy
Mice
Mice, Nude
NF-kappa B--antagonists & inhibitors
Structure-Activity Relationship
Tumor Necrosis Factor-alpha--pharmacology