Distinct pose of discodermolide in taxol binding pocket drives a complementary mode of microtubule stabilization. [electronic resource]
Producer: 20100112Description: 11664-77 p. digitalISSN:- 1520-4995
- Alkanes -- chemistry
- Animals
- Binding Sites -- drug effects
- Carbamates -- chemistry
- Cattle
- Chickens
- Deuterium Exchange Measurement
- Dimerization
- Drug Synergism
- Lactones -- chemistry
- Microtubules -- chemistry
- Paclitaxel -- chemistry
- Peptide Fragments -- blood
- Protein Binding -- drug effects
- Protein Isoforms -- blood
- Protein Stability -- drug effects
- Pyrones -- chemistry
- Tubulin -- blood
- Tubulin Modulators -- chemistry
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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