Distinct pose of discodermolide in taxol binding pocket drives a complementary mode of microtubule stabilization.

Khrapunovich-Baine, Marina

Distinct pose of discodermolide in taxol binding pocket drives a complementary mode of microtubule stabilization. [electronic resource] - Biochemistry Dec 2009 - 11664-77 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1520-4995

10.1021/bi901351q doi


Alkanes--chemistry
Animals
Binding Sites--drug effects
Carbamates--chemistry
Cattle
Chickens
Deuterium Exchange Measurement
Dimerization
Drug Synergism
Lactones--chemistry
Microtubules--chemistry
Paclitaxel--chemistry
Peptide Fragments--blood
Protein Binding--drug effects
Protein Isoforms--blood
Protein Stability--drug effects
Pyrones--chemistry
Tubulin--blood
Tubulin Modulators--chemistry