Development of high-throughput TR-FRET and AlphaScreen assays for identification of potent inhibitors of PDK1. [electronic resource]
Producer: 20100218Description: 1257-62 p. digitalISSN:- 1552-454X
- 3-Phosphoinositide-Dependent Protein Kinases
- Adenosine Triphosphate -- metabolism
- Biotinylation -- drug effects
- Fluorescence Resonance Energy Transfer -- methods
- High-Throughput Screening Assays -- methods
- Humans
- Kinetics
- Peptides -- metabolism
- Protein Kinase Inhibitors -- analysis
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins c-akt -- metabolism
- Reproducibility of Results
- Signal Transduction -- drug effects
- Structure-Activity Relationship
- Substrate Specificity -- drug effects
- Time Factors
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Publication Type: Journal Article
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