Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. [electronic resource]
Producer: 20101230Description: 833-42 p. digitalISSN:- 1559-131X
- Acute-Phase Proteins -- biosynthesis
- Apoptosis -- drug effects
- Arsenic Trioxide
- Arsenicals -- pharmacology
- Ataxia Telangiectasia Mutated Proteins
- Baculoviral IAP Repeat-Containing 3 Protein
- Carrier Proteins -- biosynthesis
- Caspase 3 -- biosynthesis
- Cell Cycle Proteins -- biosynthesis
- Cell Line, Tumor -- drug effects
- Cyclin-Dependent Kinase Inhibitor p21 -- biosynthesis
- DNA-Binding Proteins -- biosynthesis
- Gene Expression Regulation, Neoplastic -- drug effects
- Heat-Shock Proteins -- biosynthesis
- Histone Acetyltransferases -- biosynthesis
- Humans
- I-kappa B Kinase -- biosynthesis
- Inhibitor of Apoptosis Proteins -- biosynthesis
- Lipocalin-2
- Lipocalins -- biosynthesis
- Lysine Acetyltransferase 5
- Microtubule-Associated Proteins -- biosynthesis
- NF-kappa B -- antagonists & inhibitors
- Neoplasm Proteins -- biosynthesis
- Nuclear Proteins -- biosynthesis
- Oxides -- pharmacology
- Protein Serine-Threonine Kinases -- biosynthesis
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 -- biosynthesis
- Proto-Oncogene Proteins -- biosynthesis
- RNA, Messenger -- biosynthesis
- RNA, Neoplasm -- biosynthesis
- Sirtuin 1 -- biosynthesis
- Survivin
- Transcription, Genetic -- drug effects
- Tumor Protein p73
- Tumor Suppressor Proteins -- biosynthesis
- Ubiquitin-Protein Ligases
- X-Linked Inhibitor of Apoptosis Protein -- biosynthesis
- bcl-X Protein -- biosynthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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