Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin.

Momeny, Majid

Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. [electronic resource] - Medical oncology (Northwood, London, England) Sep 2010 - 833-42 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1559-131X

10.1007/s12032-009-9294-9 doi


Acute-Phase Proteins--biosynthesis
Apoptosis--drug effects
Arsenic Trioxide
Arsenicals--pharmacology
Ataxia Telangiectasia Mutated Proteins
Baculoviral IAP Repeat-Containing 3 Protein
Carrier Proteins--biosynthesis
Caspase 3--biosynthesis
Cell Cycle Proteins--biosynthesis
Cell Line, Tumor--drug effects
Cyclin-Dependent Kinase Inhibitor p21--biosynthesis
DNA-Binding Proteins--biosynthesis
Gene Expression Regulation, Neoplastic--drug effects
Heat-Shock Proteins--biosynthesis
Histone Acetyltransferases--biosynthesis
Humans
I-kappa B Kinase--biosynthesis
Inhibitor of Apoptosis Proteins--biosynthesis
Lipocalin-2
Lipocalins--biosynthesis
Lysine Acetyltransferase 5
Microtubule-Associated Proteins--biosynthesis
NF-kappa B--antagonists & inhibitors
Neoplasm Proteins--biosynthesis
Nuclear Proteins--biosynthesis
Oxides--pharmacology
Protein Serine-Threonine Kinases--biosynthesis
Protein Tyrosine Phosphatase, Non-Receptor Type 11--biosynthesis
Proto-Oncogene Proteins--biosynthesis
RNA, Messenger--biosynthesis
RNA, Neoplasm--biosynthesis
Sirtuin 1--biosynthesis
Survivin
Transcription, Genetic--drug effects
Tumor Protein p73
Tumor Suppressor Proteins--biosynthesis
Ubiquitin-Protein Ligases
X-Linked Inhibitor of Apoptosis Protein--biosynthesis
bcl-X Protein--biosynthesis