Increased tumor oxygenation and drug uptake during anti-angiogenic weekly low dose cyclophosphamide enhances the anti-tumor effect of weekly tirapazamine. [electronic resource]
Producer: 20091124Description: 777-88 p. digitalISSN:- 1873-5576
- Angiogenesis Inducing Agents -- metabolism
- Angiogenesis Inhibitors -- administration & dosage
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacokinetics
- Cell Line, Tumor
- Cyclophosphamide -- administration & dosage
- Drug Administration Schedule
- Humans
- Hypoxia -- chemically induced
- Mice
- Mice, SCID
- NADPH-Ferrihemoprotein Reductase -- metabolism
- Neoplasms -- drug therapy
- Oxygen -- metabolism
- Time Factors
- Tirapazamine
- Triazines -- administration & dosage
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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