Increased tumor oxygenation and drug uptake during anti-angiogenic weekly low dose cyclophosphamide enhances the anti-tumor effect of weekly tirapazamine.

Doloff, J C

Increased tumor oxygenation and drug uptake during anti-angiogenic weekly low dose cyclophosphamide enhances the anti-tumor effect of weekly tirapazamine. [electronic resource] - Current cancer drug targets Sep 2009 - 777-88 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1873-5576

10.2174/156800909789271503 doi


Angiogenesis Inducing Agents--metabolism
Angiogenesis Inhibitors--administration & dosage
Animals
Antineoplastic Combined Chemotherapy Protocols--pharmacokinetics
Cell Line, Tumor
Cyclophosphamide--administration & dosage
Drug Administration Schedule
Humans
Hypoxia--chemically induced
Mice
Mice, SCID
NADPH-Ferrihemoprotein Reductase--metabolism
Neoplasms--drug therapy
Oxygen--metabolism
Time Factors
Tirapazamine
Triazines--administration & dosage
Xenograft Model Antitumor Assays