Metabotropic glutamate mGluR5 receptor blockade opposes abnormal involuntary movements and the increases in glutamic acid decarboxylase mRNA levels induced by l-DOPA in striatal neurons of 6-hydroxydopamine-lesioned rats. [electronic resource]
Producer: 20100212Description: 1171-80 p. digitalISSN:- 1873-7544
- Adrenergic Agents -- toxicity
- Animals
- Corpus Striatum -- drug effects
- Dopamine Agents -- adverse effects
- Dynorphins -- metabolism
- Dyskinesia, Drug-Induced -- drug therapy
- Dystonia -- chemically induced
- Excitatory Amino Acid Antagonists -- pharmacology
- Glutamate Decarboxylase -- metabolism
- Levodopa -- adverse effects
- Male
- Neurons -- drug effects
- Oxidopamine -- toxicity
- Protein Precursors -- metabolism
- Pyridines -- pharmacology
- RNA, Messenger -- metabolism
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Receptor, Metabotropic Glutamate 5
- Receptors, Metabotropic Glutamate -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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