Metabotropic glutamate mGluR5 receptor blockade opposes abnormal involuntary movements and the increases in glutamic acid decarboxylase mRNA levels induced by l-DOPA in striatal neurons of 6-hydroxydopamine-lesioned rats.

Yamamoto, N

Metabotropic glutamate mGluR5 receptor blockade opposes abnormal involuntary movements and the increases in glutamic acid decarboxylase mRNA levels induced by l-DOPA in striatal neurons of 6-hydroxydopamine-lesioned rats. [electronic resource] - Neuroscience Nov 2009 - 1171-80 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1873-7544

10.1016/j.neuroscience.2009.07.060 doi


Adrenergic Agents--toxicity
Animals
Corpus Striatum--drug effects
Dopamine Agents--adverse effects
Dynorphins--metabolism
Dyskinesia, Drug-Induced--drug therapy
Dystonia--chemically induced
Excitatory Amino Acid Antagonists--pharmacology
Glutamate Decarboxylase--metabolism
Levodopa--adverse effects
Male
Neurons--drug effects
Oxidopamine--toxicity
Protein Precursors--metabolism
Pyridines--pharmacology
RNA, Messenger--metabolism
Random Allocation
Rats
Rats, Sprague-Dawley
Receptor, Metabotropic Glutamate 5
Receptors, Metabotropic Glutamate--antagonists & inhibitors