ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. [electronic resource]
Producer: 20100701Description: 5013-6 p. digitalISSN:- 1520-4804
- Adenosine Triphosphate -- physiology
- Animals
- Antineoplastic Agents -- chemical synthesis
- Binding Sites
- Carbamates -- chemical synthesis
- Cell Line, Tumor
- Class Ib Phosphatidylinositol 3-Kinase
- Crystallography, X-Ray
- Drug Design
- Intracellular Signaling Peptides and Proteins -- antagonists & inhibitors
- Isoenzymes -- chemistry
- Mice
- Mice, Nude
- Microsomes -- metabolism
- Models, Molecular
- Phosphatidylinositol 3-Kinases -- chemistry
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Pyrazoles -- chemical synthesis
- Pyrimidines -- chemical synthesis
- Structure-Activity Relationship
- TOR Serine-Threonine Kinases
- Urea -- analogs & derivatives
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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