ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines.

Zask, Arie

ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. [electronic resource] - Journal of medicinal chemistry Aug 2009 - 5013-6 p. digital

Publication Type: Journal Article

1520-4804

10.1021/jm900851f doi


Adenosine Triphosphate--physiology
Animals
Antineoplastic Agents--chemical synthesis
Binding Sites
Carbamates--chemical synthesis
Cell Line, Tumor
Class Ib Phosphatidylinositol 3-Kinase
Crystallography, X-Ray
Drug Design
Intracellular Signaling Peptides and Proteins--antagonists & inhibitors
Isoenzymes--chemistry
Mice
Mice, Nude
Microsomes--metabolism
Models, Molecular
Phosphatidylinositol 3-Kinases--chemistry
Protein Serine-Threonine Kinases--antagonists & inhibitors
Pyrazoles--chemical synthesis
Pyrimidines--chemical synthesis
Structure-Activity Relationship
TOR Serine-Threonine Kinases
Urea--analogs & derivatives
Xenograft Model Antitumor Assays