Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway. [electronic resource]
Producer: 20100813Description: 557-68 p. digitalISSN:- 1557-8534
- Biomarkers
- Bone Morphogenetic Protein Receptors -- genetics
- Cell Differentiation -- drug effects
- Cell Line
- Chromones -- pharmacology
- Core Binding Factor Alpha 1 Subunit -- genetics
- Embryonic Stem Cells -- cytology
- Enzyme Inhibitors -- pharmacology
- Homeodomain Proteins -- genetics
- Humans
- Immunosuppressive Agents -- pharmacology
- Inhibitor of Differentiation Protein 1 -- genetics
- Intracellular Signaling Peptides and Proteins -- antagonists & inhibitors
- Morpholines -- pharmacology
- Nanog Homeobox Protein
- Octamer Transcription Factor-3 -- genetics
- Osteoblasts -- cytology
- Osteogenesis -- drug effects
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphoinositide-3 Kinase Inhibitors
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- RNA, Messenger
- Ribosomal Protein S6 Kinases, 70-kDa -- metabolism
- Signal Transduction -- drug effects
- Sirolimus -- pharmacology
- Smad Proteins -- metabolism
- TOR Serine-Threonine Kinases
- Tacrolimus -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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