Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway.

Lee, Kyu-Won

Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway. [electronic resource] - Stem cells and development Apr 2010 - 557-68 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1557-8534

10.1089/scd.2009.0147 doi


Biomarkers
Bone Morphogenetic Protein Receptors--genetics
Cell Differentiation--drug effects
Cell Line
Chromones--pharmacology
Core Binding Factor Alpha 1 Subunit--genetics
Embryonic Stem Cells--cytology
Enzyme Inhibitors--pharmacology
Homeodomain Proteins--genetics
Humans
Immunosuppressive Agents--pharmacology
Inhibitor of Differentiation Protein 1--genetics
Intracellular Signaling Peptides and Proteins--antagonists & inhibitors
Morpholines--pharmacology
Nanog Homeobox Protein
Octamer Transcription Factor-3--genetics
Osteoblasts--cytology
Osteogenesis--drug effects
Phosphatidylinositol 3-Kinases--metabolism
Phosphoinositide-3 Kinase Inhibitors
Protein Serine-Threonine Kinases--antagonists & inhibitors
Proto-Oncogene Proteins c-akt--antagonists & inhibitors
RNA, Messenger
Ribosomal Protein S6 Kinases, 70-kDa--metabolism
Signal Transduction--drug effects
Sirolimus--pharmacology
Smad Proteins--metabolism
TOR Serine-Threonine Kinases
Tacrolimus--pharmacology