Cyclooxygenase-2 inhibitors down-regulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers. [electronic resource]
Producer: 20091015Description: 1358-66.e1-3 p. digitalISSN:- 1528-0012
- Adenomatous Polyposis Coli -- drug therapy
- Animals
- Antineoplastic Agents -- pharmacology
- Cell Line, Tumor
- Cell Survival
- Colonic Polyps -- drug therapy
- Colorectal Neoplasms -- drug therapy
- Cyclooxygenase 2 -- metabolism
- Cyclooxygenase Inhibitors -- therapeutic use
- DNA-Binding Proteins -- genetics
- Down-Regulation
- Gene Expression Profiling -- methods
- Gene Expression Regulation, Neoplastic
- Genes, APC
- Humans
- Isoxazoles -- therapeutic use
- Lactones -- therapeutic use
- Mice
- Mice, Mutant Strains
- Nuclear Receptor Subfamily 4, Group A, Member 2
- Oligonucleotide Array Sequence Analysis
- Osteopontin -- genetics
- Promoter Regions, Genetic
- RNA Interference
- Signal Transduction
- Sulfones -- therapeutic use
- Time Factors
- Transcription Factors -- genetics
- Transfection
- Wnt Proteins -- metabolism
- beta Catenin -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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