Cyclooxygenase-2 inhibitors down-regulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers.

Zagani, Rachid

Cyclooxygenase-2 inhibitors down-regulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers. [electronic resource] - Gastroenterology Oct 2009 - 1358-66.e1-3 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1528-0012

10.1053/j.gastro.2009.06.039 doi


Adenomatous Polyposis Coli--drug therapy
Animals
Antineoplastic Agents--pharmacology
Cell Line, Tumor
Cell Survival
Colonic Polyps--drug therapy
Colorectal Neoplasms--drug therapy
Cyclooxygenase 2--metabolism
Cyclooxygenase Inhibitors--therapeutic use
DNA-Binding Proteins--genetics
Down-Regulation
Gene Expression Profiling--methods
Gene Expression Regulation, Neoplastic
Genes, APC
Humans
Isoxazoles--therapeutic use
Lactones--therapeutic use
Mice
Mice, Mutant Strains
Nuclear Receptor Subfamily 4, Group A, Member 2
Oligonucleotide Array Sequence Analysis
Osteopontin--genetics
Promoter Regions, Genetic
RNA Interference
Signal Transduction
Sulfones--therapeutic use
Time Factors
Transcription Factors--genetics
Transfection
Wnt Proteins--metabolism
beta Catenin--metabolism