High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-beta and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response. [electronic resource]
Producer: 20090921Description: 1053-62 p. digitalISSN:- 1528-0020
- Adolescent
- Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
- Child
- Child, Preschool
- Chromosome Deletion
- Chromosomes, Human, Pair 6 -- genetics
- Comparative Genomic Hybridization
- Cyclin-Dependent Kinase Inhibitor p27
- Female
- Gene Dosage
- Humans
- Intracellular Signaling Peptides and Proteins -- genetics
- Male
- Multicenter Studies as Topic -- statistics & numerical data
- Neoplasm Proteins -- genetics
- Phosphatidylinositol 3-Kinases -- genetics
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy
- Prognosis
- Proto-Oncogene Proteins c-akt -- genetics
- Receptor, Notch1 -- genetics
- Signal Transduction -- genetics
- Transforming Growth Factor beta -- genetics
- Treatment Outcome
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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