ExcisaninA, a diterpenoid compound purified from Isodon MacrocalyxinD, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of its signal pathway. [electronic resource]
Producer: 20090608Description: 873-82 p. digitalISSN:- 1535-7163
- 3-Phosphoinositide-Dependent Protein Kinases
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Blotting, Western
- Breast Neoplasms -- drug therapy
- Carcinoma, Hepatocellular -- drug therapy
- Cell Proliferation -- drug effects
- Diterpenes -- pharmacology
- Drugs, Chinese Herbal -- pharmacology
- Fluorescent Antibody Technique
- Humans
- In Situ Nick-End Labeling
- Isodon -- chemistry
- Liver Neoplasms -- drug therapy
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- RNA, Messenger -- genetics
- RNA, Small Interfering -- pharmacology
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction -- drug effects
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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