ExcisaninA, a diterpenoid compound purified from Isodon MacrocalyxinD, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of its signal pathway.
Deng, Rong
ExcisaninA, a diterpenoid compound purified from Isodon MacrocalyxinD, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of its signal pathway. [electronic resource] - Molecular cancer therapeutics Apr 2009 - 873-82 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1535-7163
10.1158/1535-7163.MCT-08-1080 doi
3-Phosphoinositide-Dependent Protein Kinases
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Blotting, Western
Breast Neoplasms--drug therapy
Carcinoma, Hepatocellular--drug therapy
Cell Proliferation--drug effects
Diterpenes--pharmacology
Drugs, Chinese Herbal--pharmacology
Fluorescent Antibody Technique
Humans
In Situ Nick-End Labeling
Isodon--chemistry
Liver Neoplasms--drug therapy
Mice
Mice, Inbred BALB C
Mice, Nude
Protein Serine-Threonine Kinases--antagonists & inhibitors
Proto-Oncogene Proteins c-akt--antagonists & inhibitors
RNA, Messenger--genetics
RNA, Small Interfering--pharmacology
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction--drug effects
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
ExcisaninA, a diterpenoid compound purified from Isodon MacrocalyxinD, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of its signal pathway. [electronic resource] - Molecular cancer therapeutics Apr 2009 - 873-82 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1535-7163
10.1158/1535-7163.MCT-08-1080 doi
3-Phosphoinositide-Dependent Protein Kinases
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Blotting, Western
Breast Neoplasms--drug therapy
Carcinoma, Hepatocellular--drug therapy
Cell Proliferation--drug effects
Diterpenes--pharmacology
Drugs, Chinese Herbal--pharmacology
Fluorescent Antibody Technique
Humans
In Situ Nick-End Labeling
Isodon--chemistry
Liver Neoplasms--drug therapy
Mice
Mice, Inbred BALB C
Mice, Nude
Protein Serine-Threonine Kinases--antagonists & inhibitors
Proto-Oncogene Proteins c-akt--antagonists & inhibitors
RNA, Messenger--genetics
RNA, Small Interfering--pharmacology
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction--drug effects
Tumor Cells, Cultured
Xenograft Model Antitumor Assays