Evaluation of in vitro models for screening alkaline phosphatase-mediated bioconversion of phosphate ester prodrugs. [electronic resource]
Producer: 20090928Description: 1443-7 p. digitalISSN:- 1521-009X
- Alkaline Phosphatase -- metabolism
- Animals
- Caco-2 Cells -- enzymology
- Drug Delivery Systems
- Drug Stability
- Fluconazole -- administration & dosage
- Half-Life
- Humans
- Hydrogen-Ion Concentration
- Intestinal Absorption
- Intestines -- cytology
- Male
- Mucous Membrane -- drug effects
- Organophosphates -- administration & dosage
- Phenytoin -- analogs & derivatives
- Phosphates -- metabolism
- Prodrugs -- pharmacology
- Rats
- Rats, Sprague-Dawley
- Solubility
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Publication Type: Journal Article
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