Evaluation of in vitro models for screening alkaline phosphatase-mediated bioconversion of phosphate ester prodrugs.

Yuan, Haodan

Evaluation of in vitro models for screening alkaline phosphatase-mediated bioconversion of phosphate ester prodrugs. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Jul 2009 - 1443-7 p. digital

Publication Type: Journal Article

1521-009X

10.1124/dmd.108.026245 doi


Alkaline Phosphatase--metabolism
Animals
Caco-2 Cells--enzymology
Drug Delivery Systems
Drug Stability
Fluconazole--administration & dosage
Half-Life
Humans
Hydrogen-Ion Concentration
Intestinal Absorption
Intestines--cytology
Male
Mucous Membrane--drug effects
Organophosphates--administration & dosage
Phenytoin--analogs & derivatives
Phosphates--metabolism
Prodrugs--pharmacology
Rats
Rats, Sprague-Dawley
Solubility