Use of the metallothionein promoter-human growth hormone-releasing hormone (GHRH) mouse to identify regulatory pathways that suppress pituitary somatotrope hyperplasia and adenoma formation due to GHRH-receptor hyperactivation. [electronic resource]
Producer: 20090724Description: 3177-85 p. digitalISSN:- 1945-7170
- Adenoma -- physiopathology
- Aging
- Animals
- Cell Proliferation
- Female
- Growth Hormone-Releasing Hormone -- genetics
- Human Growth Hormone -- genetics
- Humans
- Male
- Metallothionein -- genetics
- Mice
- Mice, Knockout
- Organ Size
- Pituitary Gland -- anatomy & histology
- Pituitary Neoplasms -- physiopathology
- Proliferating Cell Nuclear Antigen -- biosynthesis
- Proto-Oncogene Proteins -- biosynthesis
- RNA, Messenger -- metabolism
- Receptors, Neuropeptide -- physiology
- Receptors, Pituitary Hormone-Regulating Hormone -- physiology
- Somatostatin -- physiology
- Somatotrophs -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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