Use of the metallothionein promoter-human growth hormone-releasing hormone (GHRH) mouse to identify regulatory pathways that suppress pituitary somatotrope hyperplasia and adenoma formation due to GHRH-receptor hyperactivation.

Luque, Raul M

Use of the metallothionein promoter-human growth hormone-releasing hormone (GHRH) mouse to identify regulatory pathways that suppress pituitary somatotrope hyperplasia and adenoma formation due to GHRH-receptor hyperactivation. [electronic resource] - Endocrinology Jul 2009 - 3177-85 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

1945-7170

10.1210/en.2008-1482 doi


Adenoma--physiopathology
Aging
Animals
Cell Proliferation
Female
Growth Hormone-Releasing Hormone--genetics
Human Growth Hormone--genetics
Humans
Male
Metallothionein--genetics
Mice
Mice, Knockout
Organ Size
Pituitary Gland--anatomy & histology
Pituitary Neoplasms--physiopathology
Proliferating Cell Nuclear Antigen--biosynthesis
Proto-Oncogene Proteins--biosynthesis
RNA, Messenger--metabolism
Receptors, Neuropeptide--physiology
Receptors, Pituitary Hormone-Regulating Hormone--physiology
Somatostatin--physiology
Somatotrophs--metabolism