Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations. [electronic resource]
Producer: 20090602Description: 2836-45 p. digitalISSN:- 1520-4804
- Aminoglycosides -- chemical synthesis
- Animals
- Bacteria -- drug effects
- COS Cells
- Cadherin Related Proteins
- Cadherins -- genetics
- Cell Survival -- drug effects
- Chlorocebus aethiops
- Codon, Nonsense -- drug effects
- Cystic Fibrosis Transmembrane Conductance Regulator -- genetics
- Cytoplasm -- drug effects
- Disease -- genetics
- Drug Discovery
- Dystrophin -- genetics
- Gentamicins -- pharmacology
- Hearing Loss -- chemically induced
- Humans
- Oligoribonucleotides -- chemistry
- Paromomycin -- pharmacology
- Protein Biosynthesis -- drug effects
- RNA Stability -- drug effects
- RNA, Ribosomal -- chemistry
- Temperature
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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