Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations.

Nudelman, Igor

Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations. [electronic resource] - Journal of medicinal chemistry May 2009 - 2836-45 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

1520-4804

10.1021/jm801640k doi


Aminoglycosides--chemical synthesis
Animals
Bacteria--drug effects
COS Cells
Cadherin Related Proteins
Cadherins--genetics
Cell Survival--drug effects
Chlorocebus aethiops
Codon, Nonsense--drug effects
Cystic Fibrosis Transmembrane Conductance Regulator--genetics
Cytoplasm--drug effects
Disease--genetics
Drug Discovery
Dystrophin--genetics
Gentamicins--pharmacology
Hearing Loss--chemically induced
Humans
Oligoribonucleotides--chemistry
Paromomycin--pharmacology
Protein Biosynthesis--drug effects
RNA Stability--drug effects
RNA, Ribosomal--chemistry
Temperature