Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing. [electronic resource]
Producer: 20090123Description: 838-48 p. digitalISSN:- 1097-4164
- 5' Untranslated Regions -- genetics
- Basic Helix-Loop-Helix Transcription Factors -- biosynthesis
- Cell Hypoxia -- drug effects
- Cell Proliferation -- drug effects
- Culture Media, Conditioned
- Dose-Response Relationship, Drug
- Endothelial Cells -- cytology
- Gene Expression Profiling
- Gene Expression Regulation -- drug effects
- Humans
- Iron -- metabolism
- Iron Chelating Agents -- pharmacology
- Iron-Regulatory Proteins -- metabolism
- Oxygen -- pharmacology
- Protein Binding -- drug effects
- Protein Biosynthesis -- drug effects
- Protein Kinases -- metabolism
- Protein Stability -- drug effects
- RNA Stability -- drug effects
- RNA, Messenger -- genetics
- Receptors, Transferrin -- genetics
- Response Elements -- genetics
- Small Molecule Libraries -- analysis
- TOR Serine-Threonine Kinases
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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