Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.

Zimmer, Michael

Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing. [electronic resource] - Molecular cell Dec 2008 - 838-48 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1097-4164

10.1016/j.molcel.2008.12.004 doi


5' Untranslated Regions--genetics
Basic Helix-Loop-Helix Transcription Factors--biosynthesis
Cell Hypoxia--drug effects
Cell Proliferation--drug effects
Culture Media, Conditioned
Dose-Response Relationship, Drug
Endothelial Cells--cytology
Gene Expression Profiling
Gene Expression Regulation--drug effects
Humans
Iron--metabolism
Iron Chelating Agents--pharmacology
Iron-Regulatory Proteins--metabolism
Oxygen--pharmacology
Protein Binding--drug effects
Protein Biosynthesis--drug effects
Protein Kinases--metabolism
Protein Stability--drug effects
RNA Stability--drug effects
RNA, Messenger--genetics
Receptors, Transferrin--genetics
Response Elements--genetics
Small Molecule Libraries--analysis
TOR Serine-Threonine Kinases