Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors. [electronic resource]
Producer: 20090206Description: 17075-84 p. digitalISSN:- 1520-5126
- Amides -- chemistry
- Cell Line, Tumor
- Crystallography, X-Ray
- Dimerization
- Drug Evaluation, Preclinical
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- chemical synthesis
- Humans
- Keto Acids -- chemical synthesis
- Models, Molecular
- Molecular Structure
- Protein Binding
- Protein Tyrosine Phosphatase, Non-Receptor Type 1 -- antagonists & inhibitors
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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