Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors.
Liu, Sijiu
Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors. [electronic resource] - Journal of the American Chemical Society Dec 2008 - 17075-84 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1520-5126
10.1021/ja8068177 doi
Amides--chemistry
Cell Line, Tumor
Crystallography, X-Ray
Dimerization
Drug Evaluation, Preclinical
Enzyme Activation--drug effects
Enzyme Inhibitors--chemical synthesis
Humans
Keto Acids--chemical synthesis
Models, Molecular
Molecular Structure
Protein Binding
Protein Tyrosine Phosphatase, Non-Receptor Type 1--antagonists & inhibitors
Structure-Activity Relationship
Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors. [electronic resource] - Journal of the American Chemical Society Dec 2008 - 17075-84 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1520-5126
10.1021/ja8068177 doi
Amides--chemistry
Cell Line, Tumor
Crystallography, X-Ray
Dimerization
Drug Evaluation, Preclinical
Enzyme Activation--drug effects
Enzyme Inhibitors--chemical synthesis
Humans
Keto Acids--chemical synthesis
Models, Molecular
Molecular Structure
Protein Binding
Protein Tyrosine Phosphatase, Non-Receptor Type 1--antagonists & inhibitors
Structure-Activity Relationship