Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways. [electronic resource]
Producer: 20081210Description: 9323-30 p. digitalISSN:- 1538-7445
- Activating Transcription Factor 4 -- genetics
- Antineoplastic Agents -- pharmacology
- Apoptosis
- Autophagy
- Boronic Acids -- pharmacology
- Bortezomib
- Cell Hypoxia
- Cell Line, Tumor
- DNA-Binding Proteins -- genetics
- Endoplasmic Reticulum -- drug effects
- Humans
- Microtubule-Associated Proteins -- metabolism
- Necrosis
- Protease Inhibitors -- pharmacology
- Protein Folding
- Pyrazines -- pharmacology
- Regulatory Factor X Transcription Factors
- Signal Transduction
- Stress, Physiological -- drug effects
- Thapsigargin -- pharmacology
- Transcription Factors -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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