Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways.

Fels, Diane R

Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways. [electronic resource] - Cancer research Nov 2008 - 9323-30 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1538-7445

10.1158/0008-5472.CAN-08-2873 doi


Activating Transcription Factor 4--genetics
Antineoplastic Agents--pharmacology
Apoptosis
Autophagy
Boronic Acids--pharmacology
Bortezomib
Cell Hypoxia
Cell Line, Tumor
DNA-Binding Proteins--genetics
Endoplasmic Reticulum--drug effects
Humans
Microtubule-Associated Proteins--metabolism
Necrosis
Protease Inhibitors--pharmacology
Protein Folding
Pyrazines--pharmacology
Regulatory Factor X Transcription Factors
Signal Transduction
Stress, Physiological--drug effects
Thapsigargin--pharmacology
Transcription Factors--genetics