Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. [electronic resource]
Producer: 20090716Description: 6215-24 p. digitalISSN:- 1528-0020
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Blotting, Western
- Cell Movement -- drug effects
- Cell Proliferation -- drug effects
- Cells, Cultured
- Chemokine CXCL12 -- genetics
- Chemotaxis -- drug effects
- Drug Resistance, Neoplasm
- Flow Cytometry
- Humans
- Immunoenzyme Techniques
- Leukemia, Experimental -- drug therapy
- Leukemia, Myeloid, Acute -- drug therapy
- Mice
- Mice, Inbred BALB C
- Mutation -- genetics
- Protein Kinase Inhibitors -- pharmacology
- Pyridines -- pharmacology
- Receptors, CXCR4 -- antagonists & inhibitors
- Stromal Cells -- drug effects
- fms-Like Tyrosine Kinase 3 -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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