Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.
Zeng, Zhihong
Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. [electronic resource] - Blood Jun 2009 - 6215-24 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1528-0020
10.1182/blood-2008-05-158311 doi
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Blotting, Western
Cell Movement--drug effects
Cell Proliferation--drug effects
Cells, Cultured
Chemokine CXCL12--genetics
Chemotaxis--drug effects
Drug Resistance, Neoplasm
Flow Cytometry
Humans
Immunoenzyme Techniques
Leukemia, Experimental--drug therapy
Leukemia, Myeloid, Acute--drug therapy
Mice
Mice, Inbred BALB C
Mutation--genetics
Protein Kinase Inhibitors--pharmacology
Pyridines--pharmacology
Receptors, CXCR4--antagonists & inhibitors
Stromal Cells--drug effects
fms-Like Tyrosine Kinase 3--genetics
Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. [electronic resource] - Blood Jun 2009 - 6215-24 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1528-0020
10.1182/blood-2008-05-158311 doi
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Blotting, Western
Cell Movement--drug effects
Cell Proliferation--drug effects
Cells, Cultured
Chemokine CXCL12--genetics
Chemotaxis--drug effects
Drug Resistance, Neoplasm
Flow Cytometry
Humans
Immunoenzyme Techniques
Leukemia, Experimental--drug therapy
Leukemia, Myeloid, Acute--drug therapy
Mice
Mice, Inbred BALB C
Mutation--genetics
Protein Kinase Inhibitors--pharmacology
Pyridines--pharmacology
Receptors, CXCR4--antagonists & inhibitors
Stromal Cells--drug effects
fms-Like Tyrosine Kinase 3--genetics