Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers. [electronic resource]
Producer: 20081210Description: 6729-37 p. digitalISSN:- 1476-5594
- Apoptosis
- Cell Line, Tumor
- Colorectal Neoplasms -- enzymology
- Cyclooxygenase 2 -- genetics
- Dinoprostone -- metabolism
- Down-Regulation
- ErbB Receptors -- genetics
- Gene Expression Regulation, Neoplastic
- Glycogen Synthase Kinase 3 -- genetics
- Glycogen Synthase Kinase 3 beta
- Humans
- Mitochondrial Proteins -- biosynthesis
- Phosphorylation
- Proline -- genetics
- Proline Oxidase -- biosynthesis
- Reactive Oxygen Species -- metabolism
- Signal Transduction
- Transcription, Genetic
- Tumor Suppressor Protein p53 -- genetics
- Wnt Proteins -- genetics
- beta Catenin -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
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