Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice. [electronic resource]
Producer: 20080930Description: 13544-9 p. digitalISSN:- 1091-6490
- Adenoma -- blood supply
- Adenomatous Polyposis Coli Protein -- genetics
- Animals
- Cell Proliferation -- drug effects
- Everolimus
- Female
- Intestinal Polyps -- metabolism
- Male
- Mechanistic Target of Rapamycin Complex 1
- Mice
- Mice, Transgenic
- Multiprotein Complexes
- Proteins
- Signal Transduction -- drug effects
- Sirolimus -- analogs & derivatives
- Survival Rate
- TOR Serine-Threonine Kinases
- Transcription Factors -- metabolism
- Wnt Proteins -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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