Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice.
Fujishita, Teruaki
Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America Sep 2008 - 13544-9 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1091-6490
10.1073/pnas.0800041105 doi
Adenoma--blood supply
Adenomatous Polyposis Coli Protein--genetics
Animals
Cell Proliferation--drug effects
Everolimus
Female
Intestinal Polyps--metabolism
Male
Mechanistic Target of Rapamycin Complex 1
Mice
Mice, Transgenic
Multiprotein Complexes
Proteins
Signal Transduction--drug effects
Sirolimus--analogs & derivatives
Survival Rate
TOR Serine-Threonine Kinases
Transcription Factors--metabolism
Wnt Proteins--metabolism
Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America Sep 2008 - 13544-9 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1091-6490
10.1073/pnas.0800041105 doi
Adenoma--blood supply
Adenomatous Polyposis Coli Protein--genetics
Animals
Cell Proliferation--drug effects
Everolimus
Female
Intestinal Polyps--metabolism
Male
Mechanistic Target of Rapamycin Complex 1
Mice
Mice, Transgenic
Multiprotein Complexes
Proteins
Signal Transduction--drug effects
Sirolimus--analogs & derivatives
Survival Rate
TOR Serine-Threonine Kinases
Transcription Factors--metabolism
Wnt Proteins--metabolism