Tumorigenic activity and therapeutic inhibition of Rheb GTPase. [electronic resource]
Producer: 20080916Description: 2178-88 p. digitalISSN:- 0890-9369
- Animals
- Antibiotics, Antineoplastic -- pharmacology
- Blotting, Western
- Cell Transformation, Neoplastic -- pathology
- Cells, Cultured
- Cellular Senescence
- Doxorubicin -- pharmacology
- Eukaryotic Initiation Factor-4E -- metabolism
- Farnesyltranstransferase -- antagonists & inhibitors
- Female
- Fibroblasts -- cytology
- Gene Dosage
- Humans
- Immunophenotyping
- Immunosuppressive Agents -- pharmacology
- Lymphoma -- metabolism
- Mechanistic Target of Rapamycin Complex 1
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Monomeric GTP-Binding Proteins -- antagonists & inhibitors
- Multiprotein Complexes
- Neuropeptides -- antagonists & inhibitors
- PTEN Phosphohydrolase -- physiology
- Phosphorylation
- Piperidines -- pharmacology
- Proteins
- Proto-Oncogene Proteins c-akt -- metabolism
- Proto-Oncogene Proteins c-myc -- physiology
- Pyridines -- pharmacology
- RNA, Messenger -- genetics
- Ras Homolog Enriched in Brain Protein
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction
- Sirolimus -- pharmacology
- TOR Serine-Threonine Kinases
- Transcription Factors -- metabolism
- Tumor Suppressor Protein p53 -- physiology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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