Tumorigenic activity and therapeutic inhibition of Rheb GTPase.

Mavrakis, Konstantinos J

Tumorigenic activity and therapeutic inhibition of Rheb GTPase. [electronic resource] - Genes & development Aug 2008 - 2178-88 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

0890-9369

10.1101/gad.1690808 doi


Animals
Antibiotics, Antineoplastic--pharmacology
Blotting, Western
Cell Transformation, Neoplastic--pathology
Cells, Cultured
Cellular Senescence
Doxorubicin--pharmacology
Eukaryotic Initiation Factor-4E--metabolism
Farnesyltranstransferase--antagonists & inhibitors
Female
Fibroblasts--cytology
Gene Dosage
Humans
Immunophenotyping
Immunosuppressive Agents--pharmacology
Lymphoma--metabolism
Mechanistic Target of Rapamycin Complex 1
Mice
Mice, Inbred C57BL
Mice, Knockout
Monomeric GTP-Binding Proteins--antagonists & inhibitors
Multiprotein Complexes
Neuropeptides--antagonists & inhibitors
PTEN Phosphohydrolase--physiology
Phosphorylation
Piperidines--pharmacology
Proteins
Proto-Oncogene Proteins c-akt--metabolism
Proto-Oncogene Proteins c-myc--physiology
Pyridines--pharmacology
RNA, Messenger--genetics
Ras Homolog Enriched in Brain Protein
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction
Sirolimus--pharmacology
TOR Serine-Threonine Kinases
Transcription Factors--metabolism
Tumor Suppressor Protein p53--physiology