Practical model-based dose finding in early-phase clinical trials: optimizing tissue plasminogen activator dose for treatment of ischemic stroke in children. [electronic resource]
Producer: 20080925Description: 2627-36 p. digitalISSN:- 1524-4628
- Adolescent
- Age Factors
- Bayes Theorem
- Brain Ischemia -- drug therapy
- Child
- Child, Preschool
- Clinical Protocols
- Clinical Trials as Topic -- methods
- Cohort Studies
- Computer Simulation
- Dose-Response Relationship, Drug
- Drug-Related Side Effects and Adverse Reactions
- Fibrinolytic Agents -- administration & dosage
- Humans
- Infant
- Models, Statistical
- Research Design
- Stroke -- drug therapy
- Tissue Plasminogen Activator -- administration & dosage
- Treatment Outcome
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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