Practical model-based dose finding in early-phase clinical trials: optimizing tissue plasminogen activator dose for treatment of ischemic stroke in children.

Whelan, Harry T

Practical model-based dose finding in early-phase clinical trials: optimizing tissue plasminogen activator dose for treatment of ischemic stroke in children. [electronic resource] - Stroke Sep 2008 - 2627-36 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1524-4628

10.1161/STROKEAHA.107.510164 doi


Adolescent
Age Factors
Bayes Theorem
Brain Ischemia--drug therapy
Child
Child, Preschool
Clinical Protocols
Clinical Trials as Topic--methods
Cohort Studies
Computer Simulation
Dose-Response Relationship, Drug
Drug-Related Side Effects and Adverse Reactions
Fibrinolytic Agents--administration & dosage
Humans
Infant
Models, Statistical
Research Design
Stroke--drug therapy
Tissue Plasminogen Activator--administration & dosage
Treatment Outcome