Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK. [electronic resource]
Producer: 20081009Description: 1760-6 p. digitalISSN:- 1524-4636
- Angiotensin II -- administration & dosage
- Animals
- Antioxidants -- pharmacology
- Aorta, Thoracic -- drug effects
- Biopterins -- analogs & derivatives
- Blood Pressure -- drug effects
- Cells, Cultured
- Disease Models, Animal
- Enzyme Inhibitors -- pharmacology
- Hypertension -- chemically induced
- Infusion Pumps, Implantable
- Inhalation Exposure
- Male
- Myosin Light Chains -- metabolism
- NADPH Oxidases -- metabolism
- Nitric Oxide Synthase -- metabolism
- Particle Size
- Particulate Matter -- toxicity
- Phosphorylation
- Rats
- Rats, Sprague-Dawley
- Reactive Oxygen Species -- metabolism
- Signal Transduction -- drug effects
- Time Factors
- Vasoconstriction -- drug effects
- rho-Associated Kinases -- antagonists & inhibitors
- rhoA GTP-Binding Protein -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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