EGF antagonizes TGF-beta-induced tropoelastin expression in lung fibroblasts via stabilization of Smad corepressor TGIF. [electronic resource]
Producer: 20080812Description: L143-51 p. digitalISSN:- 1040-0605
- Animals
- Down-Regulation -- drug effects
- Epidermal Growth Factor -- metabolism
- ErbB Receptors -- metabolism
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Fibroblasts -- cytology
- Homeodomain Proteins -- metabolism
- Humans
- Leukocyte Elastase -- metabolism
- Lung -- cytology
- MAP Kinase Kinase Kinases -- metabolism
- MAP Kinase Signaling System -- drug effects
- Mice
- Phosphorylation -- drug effects
- RNA, Small Interfering -- pharmacology
- Rats
- Rats, Sprague-Dawley
- Repressor Proteins -- metabolism
- Smad Proteins -- antagonists & inhibitors
- Transforming Growth Factor beta -- antagonists & inhibitors
- Tropoelastin -- biosynthesis
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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