EGF antagonizes TGF-beta-induced tropoelastin expression in lung fibroblasts via stabilization of Smad corepressor TGIF.

Yang, Shenghong

EGF antagonizes TGF-beta-induced tropoelastin expression in lung fibroblasts via stabilization of Smad corepressor TGIF. [electronic resource] - American journal of physiology. Lung cellular and molecular physiology Jul 2008 - L143-51 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1040-0605

10.1152/ajplung.00289.2007 doi


Animals
Down-Regulation--drug effects
Epidermal Growth Factor--metabolism
ErbB Receptors--metabolism
Extracellular Signal-Regulated MAP Kinases--metabolism
Fibroblasts--cytology
Homeodomain Proteins--metabolism
Humans
Leukocyte Elastase--metabolism
Lung--cytology
MAP Kinase Kinase Kinases--metabolism
MAP Kinase Signaling System--drug effects
Mice
Phosphorylation--drug effects
RNA, Small Interfering--pharmacology
Rats
Rats, Sprague-Dawley
Repressor Proteins--metabolism
Smad Proteins--antagonists & inhibitors
Transforming Growth Factor beta--antagonists & inhibitors
Tropoelastin--biosynthesis