Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors. [electronic resource]
Producer: 20080807Description: 4086-95 p. digitalISSN:- 1476-5594
- Amino Acid Substitution
- Antibiotics, Antineoplastic -- agonists
- Breast Neoplasms -- drug therapy
- Cell Line, Tumor
- Doxorubicin -- agonists
- Drug Resistance, Neoplasm -- drug effects
- Drug Synergism
- Female
- Gene Expression
- Humans
- Mutation, Missense
- PTEN Phosphohydrolase -- antagonists & inhibitors
- Protein Kinases -- genetics
- Proto-Oncogene Proteins c-akt -- genetics
- Ribosomal Protein S6 Kinases, 70-kDa -- genetics
- Signal Transduction -- drug effects
- Sirolimus -- agonists
- TOR Serine-Threonine Kinases
- Transfection
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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